I remember if you set it to GPIO output, accessible via AT commands ( = 4), after you can control it to be high or low without reset.
But your case seems need to reset module.
Sorry for interrupt.
According to “4118047 WPx5xx-76xx-77xx AT Command Reference_r7.1.pdf”, it is described that +WIOCFG is defined as “Reset required to apply changes: No”.
It is different from the test result and AT command description.
Could you tell us the specification which is correct in the HW point of view?